{"id":169,"date":"2019-01-26T20:26:49","date_gmt":"2019-01-26T20:26:49","guid":{"rendered":"https:\/\/frm2019.cme-congresses.com\/?page_id=169"},"modified":"2019-11-19T01:51:10","modified_gmt":"2019-11-19T01:51:10","slug":"program","status":"publish","type":"page","link":"https:\/\/frm2019.cme-congresses.com\/program\/","title":{"rendered":"Scientific Program"},"content":{"rendered":"

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Day 1, Friday, November 22, 2019<\/h3><\/div>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
<\/td>\n<\/td>\nGood morning \u2013 Welcome coffee, served prior to the start of the day<\/em><\/td>\n<\/tr>\n
<\/td>\n8:30 a.m. \u2013 9:30 a.m.<\/td>\nOpening Session<\/td>\n<\/tr>\n
<\/td>\n8:30 a.m. \u2013 8:35 a.m.<\/td>\nWelcome
\nNorbert Gleicher<\/strong>, MD
\nIn a mildly irreverent way, the FRMC every year attempts to link over 3 days evolving basic science with cutting edge clinic practice, in the process hopefully facilitating translational linkages between basic science laboratories and clinical fertility practice. The purpose is to demonstrate to clinicians what is possible and to basic scientists what is needed. FRMC has become the conference where new paradigms in reproductive medicine frequently premiere and where speakers as well as audience are encouraged to think differently. The program, therefore, evolves out of what has been happening in basic science and clinical practice in the preceding year and to where the scientific emphasis has been swaying. For the first time in 4 years, the male has been attracting significant attention and male reproductive biology is, therefore, this year a clearly featured area. Partially crossing over into male physiology, the conference also pays special attention to epigenetics. The earliest stages of embryo development never fall out of fashion because they, of course, contain the information for almost everything that is important in medicine, life, death, regeneration, immune tolerance, etc. And, clinically, the FRMC has never been bashful about addressing controversial issues, whether in presentations or in by now infamous lunch break debates. Probably the most controversial issue in this year\u2019s conference is the dramatic decline in IVF live birth rates in the U.S. and in most other regions of the world since 2010, but especially since 2013 and what causes them. Underlying causes are obviously practice changes introduced into routine IVF practice since 2010, with none, likely, more responsible than the increasing utilization of what now is called preimplantation genetic testing for aneuploidy (PGT-A), which affects IVF outcomes not only directly but also through major secondary changes in general IVF practice, like universal extended embryo culture to blastocyst-stage, embryo banking and elective single embryo transfer. All of these topics, and much more, will be subject to critical reviews and discussions. Be ready to take part!<\/span><\/em><\/span><\/td>\n<\/tr>\n
<\/td>\n8:35 a.m. \u2013 8:45 a.m.<\/td>\nThe \u201cYoung Investigator Award\u201d
\nNorbert Gleicher<\/strong>, MD and David F. Albertini<\/strong>, PhD<\/td>\n<\/tr>\n
<\/td>\n8:45 a.m. \u2013 9:30 a.m.<\/td>\nThe Breaking News Lecture<\/strong>: Self-organization of synthetic human embryos and of synthetic organs
\nAli Brivanlou<\/strong>, PhD<\/td>\n<\/tr>\n
<\/td>\n9:30 a.m. \u2013 11:00 a.m.<\/td>\nSession 1 \u2013 Essential paradigm changes: Part I
\n<\/strong>Chairs: David F. Albertini<\/strong>, PhD and Norbert Gleicher<\/strong>, MD
\n<\/strong><\/td>\n<\/tr>\n
<\/td>\n9:30 a.m. \u2013 10:00 a.m.<\/td>\nThe Opening Lecture: <\/strong>Heritable genome editing: Is there a translational path forward in the current political climate?
\nEli Y. Adashi<\/strong>, MD, MS, MA
\nLITERATURE: Adashi EY and Cohen IG. Heritable genome editing: Is a moratorium needed? JAMA 2019;9:322(2)104-105<\/em><\/span><\/td>\n<\/tr>\n
<\/td>\n10:00 a.m. \u2013 10:30 a.m.<\/td>\nContrary to decades-long dogma, pregnancy raises \u2013 not decreases \u2013 breast cancer risks
\nHazel B. Nichols<\/strong>, PhD
\nLITERATURE: Nichols et al., Breast cancer risk after recent childbirth: A pooled analysis of 15 prospective studies. Ann Intern Med 2019;170(1):22-30<\/em><\/span><\/td>\n<\/tr>\n
<\/td>\n10:30 a.m. \u2013 11:00 a.m.<\/td>\nExplaining the importance of mitochondria without pushing for a commercial product
\nDavid F. Albertini<\/strong>, PhD<\/td>\n<\/tr>\n
<\/td>\n11:00 a.m. \u2013 11:30 a.m.<\/td>\nCoffee Break, Poster Viewing & Visit the Exhibition<\/em><\/td>\n<\/tr>\n
<\/td>\n11:30 a.m. \u2013 12:30 p.m.<\/td>\nSession 2 \u2013 Essential paradigm changes: Part II
\n<\/strong>Chairs:\u00a0Zeev Shoham<\/strong>, MD and Milton Leong<\/strong>, MD<\/td>\n<\/tr>\n
<\/td>\n11:30 a.m. \u2013 12:00 p.m.<\/td>\nWhy it appears time to consider other glycoforms than FSH24 for ovarian stimulation in ART
\nT. Rajendra Kumar<\/strong>, PhD<\/td>\n<\/tr>\n
<\/td>\n12:00 p.m. \u2013 12:30 p.m.<\/td>\nNew Endocrine Society Guidelines for testosterone therapy in men with hypogonadism
\nShalender Bhasin<\/strong>, MD
\nLITERATURE: Bhasin et al., Testosterone therapy in men with hypogonadism: An Endocrine Society Clinical Practice Guideline. J Clin Edocrinol Metab 2018;103(5):1715-1744<\/em><\/span><\/td>\n<\/tr>\n
<\/td>\n12:30 p.m. \u2013 1:00 p.m.<\/td>\nGet your lunch “to-go”<\/td>\n<\/tr>\n
<\/td>\n1:00 p.m. \u20132:00 p.m.<\/td>\nLunch break debate \u2013\u00a0Thinking differently in clinical practice: Part I
\nBring your lunch
\n<\/em><\/strong>
\nIs blastocyst-stage embryo culture now the universally recommended approach to IVF or should it only be selectively applied?
\nExtended embryo culture was originally presented as a tool for embryo selection in good prognosis patients. Especially with increasing utilization of PGT-A in its current form, which requires embryo culture to blastocyst-stage and trophectoderm biopsy at that stage, extended embryo culture has become almost routine for everybody. Whether that is an appropriate approach in IVF will be the subject of a very interesting debate between two experts who have extensively written on the subject.<\/em> <\/span>Moderator: Norbert Gleicher<\/strong>, MD<\/p>\n

– It should be universally applied
\nPasquale Patrizio<\/strong>, MD, MS
\nvs.
\n– It should only be selectively applied
\nDemi\u00e1n Glujovsky<\/strong>, MD<\/td>\n<\/tr>\n

<\/td>\n2:00 p.m. \u2013 4:00 p.m.<\/td>\nSession 3 \u2013 Thinking differently in clinical practice: Part II
\n<\/strong>Chairs: David H. Barad<\/strong>, MD, MS and Pasquale Patrizio<\/strong>, MD, MS<\/td>\n<\/tr>\n
<\/td>\n2:00\u00a0p.m. \u2013 2:30 p.m.<\/td>\nWhy the year 2010 will live in the history of IVF in infamy for some time to come
\nNorbert Gleicher<\/strong>, MD
\nLITERATURE: Gleicher et al., Worldwide decline of IVF birth rates and its probable causes. Hum Reprod Open 2019;2019(3);hoz017<\/em><\/span><\/td>\n<\/tr>\n
<\/td>\n2:30 p.m. \u2013 3:00 p.m.<\/td>\nThe cold hard fact is that PGS\/PGT-A actually reduces live birth chances in most infertility patients
\nRaoul Orvieto<\/strong>, MD<\/td>\n<\/tr>\n
<\/td>\n3:00 p.m. \u2013 3:30 p.m.<\/td>\nHundreds of chromosomally-normal births bear witness to high false-positive diagnoses with PGT-A
\nPasquale Patrizio<\/strong>, MD, MS
\nLITERATURE: Patrizio et al., Worldwide live births following the transfer of chromosomally \u201cabnormal\u201d embryos after PGT\/A: results of a worldwide web-based survey. J Assist Reprod Genet 2019;36(6):1081-1090<\/em><\/span><\/td>\n<\/tr>\n
<\/td>\n3:30 p.m. \u2013 4:00 p.m.<\/td>\nAre you still retrieving oocytes in IVF cycles for all patients at the same time?
\nDavid H. Barad<\/strong>, MD, MS<\/td>\n<\/tr>\n
<\/td>\n4:00\u00a0p.m. \u2013 4:30 p.m.<\/td>\nCoffee Break, Poster Viewing & Visit the Exhibition<\/em><\/td>\n<\/tr>\n
<\/td>\n4:30\u00a0p.m. \u2013 6:30 p.m.<\/td>\nSession 4 \u2013 Thinking differently in andrology
\n<\/strong>Chairs:\u00a0Eli Y. Adashi<\/strong>, MD, MS, MA and Peter Husslein<\/strong>, MD<\/td>\n<\/tr>\n
<\/td>\n4:30\u00a0p.m. \u2013 5:00 p.m.<\/td>\nHuman spermatogonial stem cells and human spermatogenesis
\nMiles F. Wilkinson<\/strong>, PhD
\nLITERATURE: Tan K and Wilkinson MF. Human spermatogonial stem cells scrutinized under the single-cell magnifying glass. Cell Stem Cell 2019;24(2):201-203<\/em><\/span><\/td>\n<\/tr>\n
<\/td>\n5:00\u00a0p.m. \u2013 5:30 p.m.<\/td>\nGoing beyond single-cell transcriptomes of spermatogonial stem cells to understand their behavior, in vivo<\/em>
\nBrian P. Hermann<\/strong>, PhD
\nLITERATURE: Hermann et al., The mammalian spermatogenesis single-cell transcriptome. From spermatogonial stem cells to spermatids. Cell Rep 2018;25(6):1650-1667<\/em><\/span><\/td>\n<\/tr>\n
<\/td>\n5:30 p.m. \u2013 6:00 p.m.<\/td>\nCan paternal diets affect the epigenome of sperm?
\nOliver J. Rando<\/strong>, MD, PhD
\nLITERATURE: Boskovic A and Rando OJ. Transgenerational epigenetic inheritance. Annu Rev Genet 2018;52:21-41<\/em><\/span><\/td>\n<\/tr>\n
<\/td>\n6:00 p.m. \u2013 6:30 p.m.<\/td>\nLifestyle in male infertility: Diet, physical activity and body habitus
\nPeter N. Schlegel<\/strong>, MD
\nLITERATURE: Hayden et al., The role of lifestyle, in male infertility: Diet, physical activity, and body habitus. Curr Urol Rep 2018:19(7):171-180<\/em><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
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Day 2, Saturday, November 23, 2019<\/h3><\/div>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
<\/td>\n<\/td>\nGood morning \u2013 Welcome coffee, served prior to the start of the day<\/em><\/td>\n<\/tr>\n
<\/td>\n8:30 a.m. \u2013 10:30 a.m.<\/td>\nSession 5 \u2013 Thinking differently in reproductive biology: Part I<\/strong>
\nChairs:\u00a0David F. Albertini<\/strong>, PhD and Demi\u00e1n Glujovsky<\/strong>, MD<\/td>\n<\/tr>\n
<\/td>\n8:30 a.m. \u2013 9:00 a.m.<\/td>\nExtending life and health span of tissues and organs
\n<\/strong><\/em>Juan Carlos Izpisua Belmonte<\/strong>, PhD
\n<\/em>LITERATURE: Xia Y and Izpisua Belmonte JC. Design approaches for generating organ constructs. Cell Stem Cell 2019;25(3):447<\/span>
\n<\/em><\/td>\n<\/tr>\n
<\/td>\n8:45 a.m. \u2013 9:30 a.m.<\/td>\nPrinciples of cell and gene therapies in the germline
\nShoukhrat Mitalipov<\/strong>, PhD
\nLITERATURE: <\/span>Wolf et al., Principles of and strategies for germline gene therapy. Nat Med 2019;25(6):890-897<\/span><\/em><\/td>\n<\/tr>\n
<\/td>\n9:30 a.m. \u2013 10:00 a.m.<\/td>\nEmergence of pluripotency & control of tissue size: a dynamic balancing act played out in the mammalian blastocyst
\nAnna-Katerina Hadjantonakis<\/strong>, PhD<\/td>\n<\/tr>\n
<\/td>\n10:00 a.m. \u2013 10:30 a.m.<\/td>\nThe potential of in vitro maturation of primordial (non-growing) follicles
\nEvelyn E. Telfer<\/strong>, PhD
\nLITERATURE: McLaughlin et al., Metaphase II oocytes from human unilaminar follicles grown in a multi-step culture system. Mol Hum Reprod 2018;24(3):135-142<\/em><\/span>
\nThis lecture will be presented via Skype from Edinburgh, Scotland, UK<\/span><\/td>\n<\/tr>\n
<\/td>\n10:30 a.m. \u2013 11:00 a.m.<\/td>\nCoffee Break, Poster Viewing & Visit the Exhibition<\/em><\/td>\n<\/tr>\n
<\/td>\n11:00 a.m. \u2013 12:30 p.m.<\/td>\nSession 6 \u2013 Are we underestimating IVF risks? Part I
\n<\/strong>Chairs:\u00a0Nicole Noyes<\/strong>, MD and Raoul Orvieto<\/strong>, MD<\/td>\n<\/tr>\n
<\/td>\n11:00 a.m. \u2013 11:30 a.m.<\/td>\nThe risk of epigenetic reprogramming in association with IVF
\nJohn McCarrey<\/strong>, PhD<\/td>\n<\/tr>\n
<\/td>\n11:30 a.m. \u2013 12:00 p.m.<\/td>\nIs monozygotic twinning increased with IVF?
\nNicole Noyes<\/strong>, MD<\/td>\n<\/tr>\n
<\/td>\n12:00 p.m. \u2013 12:30 p.m.<\/td>\nIs embryo cryopreservation causing macrosomia \u2013 and what else?
\nRaoul Orvieto<\/strong>, MD<\/td>\n<\/tr>\n
<\/td>\n12:30 p.m. \u2013 1:00 p.m.<\/td>\nGet your lunch “to-go”<\/td>\n<\/tr>\n
<\/td>\n1:00 p.m. \u2013 2:00 p.m.<\/td>\nLunch break debate \u2013 Essential paradigm changes: Part III
\nBring your lunch
\n<\/em><\/strong>
\n<\/em><\/strong>Is uterine transplantation medically, ethically and economically sustainable?
\nMats Br\u00e4nnstr\u00f6m, MD, deservedly received worldwide acclaim for not only demonstrating the feasibility of uterine transplantation in humans and their ability to function in pregnancy, but also for the tour de force of his research efforts over many years that ultimately led to birth of the first child carried in a transplanted uterus. Based on his and his team\u2019s groundbreaking work, uterine transplantation has become available in a number of medical centers around the world and an increasing number of births is steadily being reported. Uterine transplantation is, however, a highly invasive procedure for donor as well as recipient, and carries with it a very significant price tag. Following the tradition of the FRMC to addres<\/em><\/span>s controversial subjects, this Lunch Break Debate will address these controversies. We greatly appreciate Mats Br\u00e4nnstr\u00f6m\u2019s participation as proponent and David Barad\u2019s as, at least theoretical, opponent.<\/em><\/span>
\nLITERATURE: Castelle\u00f3n et al., The history behind successful uterine transplantation in humans. JBRA Assist Reprod 2017.<\/em><\/span><\/p>\n

Moderator: Norbert Gleicher, MD<\/p>\n

-Yes, it is fully sustainable!
\nMats Br\u00e4nnstr\u00f6m<\/strong>, MD
\nvs.
\n– No, it raises concerns!
\nDavid H. Barad<\/strong>, MD, MS<\/td>\n<\/tr>\n

<\/td>\n2:00 p.m. \u2013 3:30 p.m.<\/td>\nSession 7 \u2013 Are we underestimating IVF risks? Part II
\n<\/strong>Chairs:\u00a0David H. Barad<\/strong>, MD, MS\u00a0and Mats Br\u00e4nnstr\u00f6m<\/strong>, MD
\n<\/em><\/td>\n<\/tr>\n
<\/td>\n2:00\u00a0p.m. \u2013 2:30 p.m.<\/td>\nAre reported risks of increased congenital abnormalities and long-term effects on offspring from IVF real?
\nAndrea Weghofer<\/strong>, MD, PhD, MS, MBA<\/td>\n<\/tr>\n
<\/td>\n2:30 p.m. \u2013 3:00 p.m.<\/td>\nHow much of a risk is OHSS still in current IVF practice?
\nZeev Blumenfeld<\/strong>, MD
\nLITERATURE: Blumenfeld Z. The ovarian hyperstimulation syndrome. Vitam Horm 2018;107:423-451<\/em><\/span><\/td>\n<\/tr>\n
<\/td>\n3:00 p.m. \u2013 3:30 p.m.<\/td>\nDetection of mosaicism from single-cell expression data and implications for PGT-A
\nRajiv C. McCoy<\/strong>, PhD<\/td>\n<\/tr>\n
<\/td>\n3:30\u00a0p.m. \u2013 4:00 p.m.<\/td>\nCoffee Break, Poster Viewing & Visit the Exhibition<\/em><\/td>\n<\/tr>\n
<\/td>\n4:00\u00a0p.m. \u2013 6:30 p.m.<\/td>\nSession 8 \u2013 Thinking differently in clinical practice: Part III
\n<\/strong>Chairs:\u00a0Zeev Blumenfeld<\/strong>, MD and Andrea Weghofer<\/strong>, MD, PhD, MS, MBA<\/td>\n<\/tr>\n
<\/td>\n4:00\u00a0p.m. \u2013 4:30 p.m.<\/td>\nNew insights into recurrent pregnancy loss
\nJan J.<\/strong> Brosens<\/strong>, MD, PhD
\nLITERATURE: Ewinton et al., New insights into the mechanisms underlying recurrent pregnancy loss. J Obstet Gynecol Res 2019;45(2):258-265<\/em><\/span><\/td>\n<\/tr>\n
<\/td>\n4:30\u00a0p.m. \u2013 5:00 p.m.<\/td>\nCan we activate dormant follicles, resistant to stimulation: The concept of in vivo, rather than in vitro \u201covarian tissue rejuvenation\u201d?
\nDavid H. Barad<\/strong>, MD, MS<\/td>\n<\/tr>\n
<\/td>\n5:00 p.m. \u2013 5:30 p.m.<\/td>\nUsing NGS, concordance in ploidy between cleavage- and blastocyst-stages and between trophectoderm and inner cell mass in human embryos is lower than previously reported
\nHuman M. Fatemi<\/strong>, MD, PhD
\nLITERATURE: Li\u00f1\u00e1 et al., Clinical reassessment of human embryo ploidy status between cleavage and blastocyst stage by Next Generation Sequencing. PLoS One 2018;13(8):e0201652<\/em><\/span><\/td>\n<\/tr>\n
<\/td>\n5:30 p.m. \u2013 6:00 p.m.<\/td>\nHow delayed childbearing, paradoxically contributes to the multiple birth epidemic in the US
\nEli Y. Adashi<\/strong>, MD, MS, MA<\/td>\n<\/tr>\n
<\/td>\n6:00 p.m. \u2013 6:30 p.m.<\/td>\nChanging utilization of third-party egg donation in US IVF practice
\nNobert Gleicher<\/strong>, MD<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
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Day 3, Sunday, November 24, 2019<\/h3><\/div>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
<\/td>\n<\/td>\nGood morning \u2013 Welcome coffee, served prior to the start of the day<\/em><\/td>\n<\/tr>\n
<\/td>\n8:30 a.m. \u2013 10:30 a.m.<\/td>\nSession 9 \u2013 Hot topics<\/strong>
\nChairs:\u00a0Human M. Fatemi<\/strong>, MD, MS\u00a0and Sherman J. Silber<\/strong>, MD<\/td>\n<\/tr>\n
<\/td>\n8:30 a.m. \u2013 9:00 a.m.<\/td>\nWhere are we in our search for human ovarian stem cells?
\nEvelyn E. Telfer<\/strong>, PhD
\nLITERATURE: Telfer EE and Anderson RA. The existence and potential of germline stem cells in the adult mammalian ovary. Climacteric 2019;22(1):22-26<\/em><\/span>
\nThis lecture will be presented via Skype from Edinburgh, Scotland, UK<\/span><\/td>\n<\/tr>\n
<\/td>\n8:45 a.m. \u2013 9:30 a.m.<\/td>\nMapping the emergent organotypic landscape of the embryo at single cell resolution
\nSonja Nowotschin<\/strong>, PhD
\nLITERATURE: Nowotschin et al., The emergent landscape of the mouse gut endoderm at single-cell resolution. Nature 2019; 569(7756):361-367 <\/em><\/span><\/td>\n<\/tr>\n
<\/td>\n9:30 a.m. \u2013 10:00 a.m.<\/td>\nSelf-correction of aneuploidy in human blastocysts and self-organizing human gastruloids
\nMin Yang<\/strong>, PhD<\/td>\n<\/tr>\n
<\/td>\n10:00 a.m. \u2013 10:30 a.m.<\/td>\nHigh resolution in utero imaging of early primate embryogenesis
\nRohan Soman<\/strong><\/td>\n<\/tr>\n
<\/td>\n10:30 a.m. \u2013 11:00 a.m.<\/td>\nCoffee Break<\/em><\/td>\n<\/tr>\n
<\/td>\n11:00 a.m. \u2013 2:00 p.m.<\/td>\nClosing Session \u2013 Interesting most recent or yet unpublished studies
\n<\/strong>Chairs:\u00a0David F. Albertini<\/strong>, PhD and Norbert Gleicher<\/strong>, MD<\/td>\n<\/tr>\n
<\/td>\n11:00 a.m. \u2013 11:20 a.m.<\/td>\nLate-Breaking News<\/strong>: Trial of human skin biopsies to germ-cells
\nSherman J. Silber<\/strong>, MD
\n<\/em><\/td>\n<\/tr>\n
<\/td>\n11:20 a.m. \u2013 11:40 a.m.<\/td>\nPreliminary results of intraovarian PRP injections
\nDavid H. Barad<\/strong>, MD, MS<\/td>\n<\/tr>\n
<\/td>\n11:40 a.m. \u2013 12:00 p.m.<\/td>\nA totally surprising rebound effect in complete non-responders in search of an explanation
\nNorbert Gleicher<\/strong>, MD
\n<\/em><\/td>\n<\/tr>\n
<\/td>\n12:00 p.m. \u2013 12:20 p.m.<\/td>\nSubfertility in adult life due to epigenetic reprogramming of the fetal ovary in utero: The example of gestational diabetes
\nAritro Sen<\/strong>, PhD
\nLITERATURE:\u00a0Sinha et al., Gestational diabetes epigenetically reprograms the CART promoter in fetal ovary, causing subfertility in adult life. Endocrinology 2019;160(7):1684-1700<\/em> <\/span><\/td>\n<\/tr>\n
<\/td>\n12:20 p.m. \u2013 12:40 p.m.<\/td>\nAdult bone marrow progenitors become decidual cells and contribute to embryo implantation and pregnancy
\nReshef Tal<\/strong>, MD, PhD
\n<\/em>LITERATURE: <\/span>Tal R et al., Adult bone marrow progenitors become decidual cells and contribute to embryo implantation and pregnancy. PLoS Biol 2019;17(9):e300421<\/span>
\n<\/em><\/td>\n<\/tr>\n
<\/td>\n12:40 p.m. \u2013 1:00 p.m.<\/td>\nQuestions & Answers
\n<\/em><\/td>\n<\/tr>\n
<\/td>\n1:00 p.m. \u2013 1:45 p.m.<\/td>\nThe Closing Lecture<\/strong>: Chromosomal instability in cancer: Relevance to the early embryo?
\nSamuel Bakhoum<\/strong>, MD, PhD
\n<\/em>LITERATURE: Bakhoum SF and Cantley LC. The multifaceted role of chromosomal instability in cancer and its microenvironment. Cell 2018;174(6):1347-1360<\/em><\/span>
\n<\/em><\/td>\n<\/tr>\n
<\/td>\n1:45 p.m. \u2013 2:00 p.m.<\/td>\nClosing remarks
\nNorbert Gleicher<\/strong>, MD<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
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